The reasons cited were limited efficacy (about one additional sexually satisfying event per month), concerns about safety and potential adverse effects with long-term therapy, and concerns about inappropriate off-label use. In contrast to these high doses, there is little support for the notion that testosterone is a critical hormone for sexual desire and function in women under normal physiological circumstances. Although testosterone has been found to be effective at improving sexual function in postmenopausal women, the doses employed have been supraphysiological. Testosterone therapy is effective in the short-term for the treatment of hypoactive sexual desire disorder (HSDD) in women.
